Senior Scientist - Antibody Platform

RxBiologics Limited

Closing Date: 05/04/2024

The RxCelerate group of companies provides a platform for out-sourced drug discovery and development services and has a client base ranging from virtual biotech companies to some of the top 15 global pharmaceutical companies. We design and deliver complete drug development programmes from inception through to and including Phase II clinical studies. RxBiologics is a subsidiary of RxCelerate with a focus on the delivery of biologics drug discovery. Our aim is to become the antibody drug developer of choice for the UK’s venture backed biotech start-ups and outsourced pharma projects.

RxBiologics has an excellent opportunity for an enthusiastic and motivated scientist to join us and help develop our services to support our growing client base. The position is based within the RxBiologics team, working at the Babraham Research Campus, a leading site within the Cambridge biotechnology hub.

THE ROLE
The successful candidate will have a strong interest in biologics display platforms. They will have an outstanding working knowledge of molecular biology techniques and approaches used in antibody library construction that will enable them to deliver high quality phage display libraries. The role also includes leading the validation of antibody libraries through implementing phage display campaigns, hit identification and Sanger and NGS sequencing. This is a full-time, lab-based role and it is expected that the successful candidate will perform work independently to a high standard and deliver to timelines. They will have a proactive approach, be an exceptional team-worker and motivated to learn, lead troubleshooting efforts and to take on additional responsibilities.

If you would like to apply, please do so via this link Senior Scientist – Antibody Platform (aptrack.co)

Main Responsibilities
• Isolation of antibody genes from biological samples such as PBMCS
• Construct antibody phage display antibody libraries
• Analysis of antibody sequences at the DNA and protein level
• Performing phage display campaigns
• Hit screening by biochemical plate-based assays (e.g., ELISAs and TR-FRET assays)
• Accurate and high-quality documentation of processes, protocols and inventories.
• Independently plan and troubleshoot experimental work.
• Analysis and interpretation of experimental data.
• Maintenance of experimental records and delivery of high-quality reports.

Essential Skills/Requirements
• PhD or equivalent experience within a relevant technical area and extensive biologics discovery knowledge gained from working within the pharmaceutical/biotechnology industry.
• Demonstrated interest in biologics and knowledge of the discovery process.
• Experienced in RNA isolation, QC and reverse transcription.
• Experienced in the isolation of PBMCs from blood samples.
• Proven molecular biology skills, with experience of cloning DNA libraries; RT-PCR and digestion and ligation and bacterial electroporation.
• Sequencing analysis at the DNA and protein level; antibody sequence analysis an advantage.
• Experienced in handling bacteriophage, transduction and selections.
• Working knowledge of biochemical techniques e.g., ELISA, homogeneous assays, SPR or BLI.
• Ability to independently interpret data, troubleshoot and set up new workflows.
• Proven track record of delivering projects to timely completion.
• Excellent organisational skills with ability to prioritise multiple tasks.
• Demonstrated ability to work effectively in a team.
• Proactive approach to resolving technical challenges.
• Strong attention to detail.
• Good interpersonal, communication and presentation skills.

If you would like to apply, please do so via this link Senior Scientist – Antibody Platform (aptrack.co)

RxBiologics offers a competitive salary with an annual bonus scheme and company benefit package.