Scientist, Assay Development

F-star

Closing Date: 05/01/2022

A BIT ABOUT US… 
At F-star, we are dedicated to developing next generation immunotherapies to transform the lives of patients with cancer. We develop mAb², a novel class of disruptive bispecific antibody-based therapies that have the potential to overcome tumor resistance and restore anti-cancer immunity and responsiveness. 

We are committed to delivering life-changing treatments for the estimated 80% of patients with cancer who currently fail to have a durable response to immunotherapies. 

Our wholly owned pipeline shows focused and potent immune activation, with a promising safety profile to date. 

We’re an agile, international team with dual headquarters in Cambridge, UK and Cambridge, Massachusetts. We empower our teams to decide where and when they work to deliver our goals. 

 

YOUR ROLE IN OUR TEAM: 
Working within our Bioanalytical and Biomarker Development Team, you will be central to the progression of projects through pre-clinical and clinical stages. Your role will be lab-based and responsible for developing and qualifying/validating in vitro assays either for analysing non-regulated study samples in our Cambridge facility, or for transfer and technical supervision of work conducted within contract research organisations. You’ll work in a matrix with other functions to translate Project requirements into a bioanalytical strategy and provide data for key Project milestones. 

 

YOUR KEY RESPONSIBILITIES WILL INCLUDE: 

  • Act as the Bioanalytical/Biomarker Lead on multi-functional Project Team to contribute to project goals, provide direction on bioanalytical strategies and give progress updates to key stakeholders. 
  • Design and qualify/validate methods (e.g. PK, ADA, nAb, serum biomarkers) to support analytical strategies in line with Project goals. Carry out analysis of data to identify issues and implement necessary changes. 
  • Responsible for technical supervision of other scientists involved in developing bioanalytical and biomarker assays 
  • Lead or contribute to technical troubleshooting with outsourced bioanalytical and biomarker assays, including but not limited to PK, ADA, serum biomarkers, flow cytometry assays. 
  • Communicate effectively with the Principal Scientist to maintain consistent cross-project scientific approaches and appropriate team resourcing. 

 

A BIT ABOUT YOU: 
We’re looking for someone who is enthusiastic and motivated to succeed. You’ll be great at problem solving, with a strong attention to detail. Effective communication skills are important along with the proven ability to work well within teams, both in person and in a virtual environment. 

 

YOUR SKILLS, KNOWLEDGE AND EXPERIENCE: 

Essential: 

  • Minimum 2 years of assay development experience (PK, ADA and matrix biomarkers) within a biotech/biopharma/academic setting 
  • Experience in flow cytometry 
  • Experience with cell-based assays 
  • Proficient in designing and optimising immunological assays and/or biological experiments for robustness and reliable data quality, interpretation of data and trouble shooting 
  • Experience understanding factors affecting assay robustness and assay performance 
  • Excellent record-keeping and ensuring high levels of data quality 
  • Enthusiasm to learn and optimise new methods 
  • Strong communication skills and proven ability to work well in teams and independently in both face to face and virtual settings 

Desirable: 

  • Experience with cell-based receptor occupancy assay 
  • Experience with neutralising antibody assays 
  • Experience with R programming (e.g. ggplot, tidyverse) or other programming language 

 

WHAT WE CAN OFFER TO YOU: 
We get things done, we keep things simple and we’re driven by the science. We’re ambitious so we work hard to create an environment where we can take smart risks. We want to be innovative so encourage debate and collaboration to challenge the usual way of doing things. We love our celebrations, socialising and perks, which make F-star a fun and diverse place to work. And most of all, everyone has the opportunity to make a difference. 

Benefits: 

  • Pension (8% Employer contribution) 
  • Equity Incentives 
  • Private Medical Insurance and Health Cash Plan 
  • Life assurance 
  • 25 days paid holiday, plus the option to buy 5 days 
  • Travel insurance 
  • Enhanced Maternity, Paternity, Adoption pay 
  • Agile working opportunities 

 

OTHER DETAILS: 
This role is to be based in Cambridge, UK. Our laboratories and office space are based on the Babraham Research Campus, South Cambridgeshire. 

This is a full-time position working 37.5 hours per week. F-star is proud to fully embrace agile working which gives you options in how, where and when you get your work done, including flexible working hours and home working. 

 

NEXT STEPS… 
If you feel this role is right for you, we’d love to hear from you. 

To apply, please visit our website: https://www.f-star.com/about/careers/ and upload your CV for us to view. Those that shine brightest will be contacted to discuss the role further, however, we aim to get back to everyone with a response either way. 

We may choose to close the role sooner than the application closing date depending on volume of candidates and so we encourage early applications. 

If, along the way, you experience any difficulties with applying via our website, please email HR@f-star.com

We aspire to be a diverse and inclusive workplace and strongly encourage suitably qualified applicants from a wide range of backgrounds to apply. 

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