Senior Director Oncology Translational Science

Mission Therapeutics

Closing Date: 31/01/2022

Key Responsibilities of the role will include

• Lead oncology projects from lead optimization through candidate selection and into early clinical development

• Build an oncology translational science team to design and operationalize oncology translational strategies

• Use translational oncology expertise to build upon target validation biology and progress DUB targets towards clinical evaluation in defined patient populations

• Identify and select target/mechanism appropriate in vivo models which support patient populations of interest.

• Drive oncology biomarker function and patient stratification marker development

• Develop and implement research and clinical-level assays, along with data analysis, interpretation, and report generation

• Work closely with the research team to identify novel biomarkers

• Manage/oversee CROs responsible for the generation of in vivo preclinical oncology data and exploratory/development biomarker data

• Transition research assays to LDTs and contribute to CDx development

• Contribute to clinical documents such as, INDs, IBs, regulatory submissions, laboratory manuals and clinical protocols

• Function as a scientific thought leader inside the company for cutting edge biomarker approaches

Qualifications, Skills and Experience

• PhD in cancer biology, immunology, genomics, biochemistry or molecular/cellular biology

• 10+ years of pharmaceutical or biotechnology industry experience in oncology or cancer immunotherapy (including DDR) with an emphasis on translational research and clinical biomarkers

• Established network of KOLs to support Mission oncology programs

• Proven track record of transitioning oncology biomarkers from the bench to the clinic

• Significant oncology publication record, including mechanisms and biomarkers

• Significant experience with key oncology CROs for preclinical models and patient ID biomarker development

• Experience with DDR, oncogenic driver genes/mutations, Wnt signaling pathways is preferred

• Excellent communication skills and the ability present results in a clear and concise manner

• Excellent interpersonal skills, personal integrity, professional manner and ability to gain respect and develop good working relationships with cross functional personnel at all levels


We offer a competitive salary along with a contributory pension scheme and other excellent benefits.

If you would like to apply for the position, please send your CV with a covering letter to

The closing date for applications is 31 January 2022.

In order to comply with UK employment legislation, all applicants for positions at Mission must have the right to work in the UK. In the event that a job offer is made, you will be required to provide evidence of your right to work in the UK before you commence employment with Mission.

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