Insmed is building its Drug Metabolism and Pharmacokinetics (DMPK) capabilities in Cambridge, UK, and we're seeking an outstanding and forward-thinking DMPK Director to lead this exciting endeavor. Reporting directly to the VP of Chemistry, you will be the first dedicated discovery DMPK hire at our Cambridge site, playing a meaningful role in guiding our growing pipeline of small molecule and oligonucleotide therapeutics. You will have the opportunity to define our DMPK strategy, optimize our external partnerships and interact with our US DMPK team, whilst demonstrating deep expertise in DMPK, PK/PD modeling and drug discovery.
ResponsibilitiesDevelop and nurture our UK discovery DMPK strategy.Forge positive relationships with external vendors to ensure rapid access to quality DMPK data.Orchestrate the design, oversight, and interpretation of critical ADME and PK studies (in vitro/in vivo).Partner closely with multidisciplinary teams across our UK discovery projects and US sites.Provide pivotal DMPK guidance on candidate selection, dose optimization, and human PK projections.Lead on external CROs and partnerships, ensuring excellence in data delivery.Apply the power of modelling & simulation (PK/PD, PBPK) to drive informed decisions.Maintain a pulse on the evolving landscape of DMPK regulations and industry practice.What we are looking forPhD in Pharmacokinetics, Pharmacology, Pharmaceutical Sciences, or a related field.A minimum of 10 years dynamic DMPK experience within the biotech/pharmaceutical industry, ideally within smaller, multifaceted organizations.A consistent record of meaningful contributions leading to successful development candidate nominations.Proven success in handling Contract Research Organizations (CROs) and encouraging effective cross-functional collaborations.Outstanding communication, critical thinking, and problem-solving competence.This role will require you to work from our brand-new state-of-the-art offices and labs situated in Babraham Research Campus, South Cambridge. Hybrid working is offered based on specific business needs and the role requirements.Experience working with antisense oligonucleotide (ASO) therapeutics, and compounds targeting the central nervous system (CNS) would desirable.Additional Information Insmed Incorporated is an Equal Opportunity employer. We do not discriminate in hiring on the basis of physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at TotalRewards@insmed.com and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.Applications are accepted for 5 calendar days from the date posted or until the position is filled.https://insmed.com/culture/careers/#