Senior Research Associate, Drug Discovery

F-star Therapeutics

Closing Date: 30/06/2022

We’re looking for a Senior Research Associate to join our Biology department, reporting into the Senior Principal Scientist. This role will be responsible for executing and analysing experiments to further our understanding of the mechanism of action and deeper biology of our bispecific molecules. In this lab-based position, you’ll use your knowledge, expertise, and experience of practical and academic tumour immunology to contribute across multi-functional project teams. You will demonstrate good judgement and effective decision making in applying your expertise in understanding the underlying immunology response(s) to bispecific antibody intervention.

YOUR KEY RESPONSIBILITIES WILL INCLUDE:

Independently design and execute experiments in line with project goals and strategy to achieve project plans and milestones

Use expertise to help develop novel and refine/optimise existing in vitro assays used to characterise bispecific molecules

Provide key immunological expertise to the team and apply knowledge of multiple disciplines or technological processes to affect program/project direction

Work collaboratively with others, effectively communicating with management and co-workers to enhance preclinical and translational capabilities and processes

Communicate ideas, experimental strategy, methods, and results to line managers and present to project teams

Contribute to solving experimental or technical problems of programmes and projects

Maintain an up-to-date awareness of scientific literature and competitive intelligence relevant to F-star projects

A BIT ABOUT YOU:

You’ll have a BSc or Msc in a biological subject (ideally with a relevant focus on Immunology, Oncology or Pharmacology) or equivalent industry experience. Whilst not essential, experience working on drug discovery and/or translational research projects, in academia or industry, would be an advantage.

We’re looking for someone who is adaptable, keen to learn and confident in delivering their work with limited supervision. You’ll be organised with strong attention to detail. You will be enthusiastic and keen to learn and optimize new methods. Strong communication skills are important along with the proven ability to work well within teams, both in person and in a virtual environment. This is a busy role with deadlines to meet and so you’ll be able to prioritise your workload and adapt quickly to change when needed. 

YOUR SKILLS, KNOWLEDGE AND EXPERIENCE:

Essential

Multi-colour flow cytometry

Aseptic cell culture technique

Experience with human primary PBMC culture and associated in vitro assays (e.g. T cell activation, NK cell activity, cytokine release assays etc)

Technically competent in the ex vivo characterisation of murine models, preferably in an oncology setting (cell isolation, flow cytometry antibody staining etc)

Ability to analyse immune cell populations by multi-colour flow cytometry (e.g. TIL analysis).

Proven experience designing and optimising biological and immunological assays for robustness and reliable data quality (e.g. ELISA, MSD).

Desirable

Experience and/or knowledge of pharmacokinetic and pharmacodynamic analysis relevant to immuno-oncology

Experience of analysing data from experiments to assess gene expression changes (RT-PCR, gene expression array, nanostring)

Experience of syngeneic mouse models including dissociation of murine tissue to single cell suspensions and subsequent analysis would be an advantage

WHAT WE CAN OFFER TO YOU:

We get things done, we keep things simple and we’re driven by the science. We’re ambitious so we work hard to create an environment where we can take smart risks. We want to be innovative so encourage debate and collaboration to challenge the usual way of doing things. We love our celebrations, socialising and perks, which make F-star a fun and diverse place to work.  And most of all, everyone has the opportunity to make a difference.

Benefits:

Pension (8% Employer contribution)

Equity Incentives

Private Medical Insurance and Health Cash Plan

Life assurance

25 days paid holiday, plus the option to buy 5 days

Enhanced Maternity, Paternity, Adoption pay

Agile working opportunities

OTHER DETAILS:                            

This role is to be based from our laboratories and office space based on the Babraham Research Campus, South Cambridgeshire.

This is a full time position working 37.5 hours per week. While this is primarily a laboratory-based role, F-star is proud to fully embrace agile working which gives you options in how, where and when you get your work done, including flexible working hours and home working.

NEXT STEPS…

If you feel this role is right for you, we’d love to hear from you.

To apply, please visit our website: https://f-star.com/careers/  and upload your CV for us to view. Those that shine brightest will be contacted to discuss the role further, however, we aim to get back to everyone with a response either way.

We may choose to close the role sooner than the application closing date depending on volume of candidates and so we encourage early applications.

If, along the way, you experience any difficulties with applying via our website, please email HR@f-star.com.

We aspire to be a diverse and inclusive workplace and strongly encourage suitably qualified applicants from a wide range of backgrounds to apply.

As part of our compliance in relation to the General Data Protection Regulations 2018 (GDPR) you can find our ‘Candidate Privacy Notice’ on the careers section of website.