SENIOR RESEARCH ASSOCIATE, CELL BASED ASSAYS

F-star

Closing Date: 01/02/2022

SENIOR RESEARCH ASSOCIATE, CELL BASED ASSAYS

A BIT ABOUT US…

At F-star, we are dedicated to developing next generation immunotherapies to transform the lives of patients with cancer. We develop mAb², a novel class of disruptive bispecific antibody-based therapies that have the potential to overcome tumour resistance and restore anti-cancer immunity and responsiveness.

We are committed to delivering life-changing treatments for the estimated 80% of patients with cancer who currently fail to have a durable response to immunotherapies.

Our wholly owned pipeline shows focused and potent immune activation, with a promising safety profile to date.

We’re an agile, international team with dual headquarters in Cambridge, UK and Cambridge, Massachusetts. We empower our teams to decide where and when they work to deliver our goals.

YOUR ROLE IN OUR TEAM:

You will be working in a unique, cross functional role within early drug discovery projects and CMC development, with a focus on cell-based assays. You will be a key contributor to the design, development and execution of in vitro biological assays to support drug discovery lead evaluation and candidate selections, as well as subsequent CMC development of novel bispecific antibodies.

YOUR KEY RESPONSIBILITIES WILL INCLUDE:

• Design and perform in vitro assays (e.g. T cell activation assay, killing assay, potency assay, ELISA)

• Author and follow SOPs, undertake analysis, interpretation and reporting of your results

• Ensure experiments and data management activities result in robust quality of data

• Communicate ideas, experimental strategy methods and results to manager, team and company where appropriate

• Operate all items of equipment or IT needed for experimentation, data analysis, storage, data entry and reporting

• Contribute to the maintenance of reagents and general lab facilities

A BIT ABOUT YOU:

We’re looking for someone who is adaptable, keen to learn and confident in delivering work with limited supervision. You’ll be organised with strong attention to detail with an ability to keep clear records. You will be able to maintain rigid controls and analysis during multiple experiments. Strong communication skills are important along with the proven ability to work well within teams, both in person and in a virtual environment. This is a busy role with deadlines to meet and so you’ll be able to prioritise your workload and adapt quickly to change when needed.

YOUR SKILLS, KNOWLEDGE AND EXPERIENCE:

Essential:

• BSc degree or equivalent in a biological subject, with relevant focus on biochemistry, cell biology or pharmacology with substantial relevant lab/industry experience

• Proficient in the following: cell culture, in vitro immune cell activation assays, analysis and purification of primary human immune cells

• Proficient in aseptic technique and best practice in pipetting

• Proven experience in experimental design, interpretation of data, trouble shooting

• Working experience in structured assay design, record keeping and understanding of assay robustness and levels of data quality

• Competent knowledge of in vitro assay development and data generation in a regulated environment and a keen interest in learning more technical principles, processes, and concepts related to regulatory requirements, designing experiments, in vitro techniques, and cancer biology

Desirable:

• Understanding of potency assay principles

• Experience in immunological phenotyping by flow cytometry

• Knowledge in immunology and/or cancer biology

• Knowledge in the development of antibody-based therapeutics and CMC

• Previous relevant industry experience in a regulated environment (GLP, GMP)

WHAT WE CAN OFFER TO YOU:

We get things done, we keep things simple and we’re driven by the science. We’re ambitious so we work hard to create an environment where we can take smart risks. We want to be innovative so encourage debate and collaboration to challenge the usual way of doing things. We love our celebrations, socialising and perks, which make F-star a fun and diverse place to work. And most of all, everyone has the opportunity to make a difference.

Benefits:

• Pension (8% Employer contribution)

• Equity Incentives

• Private Medical Insurance and Health Cash Plan

• Life assurance

• 25 paid holiday, plus the option to buy 5 days

• Travel insurance

• Enhanced Maternity, Paternity, Adoption pay

• Agile working opportunities

OTHER DETAILS:

This role is to be based in Cambridge, UK. Our laboratories and office space are based on the Babraham Research Campus, South Cambridgeshire.

This is a full time position working 37.5 hours per week. F-star is proud to fully embrace agile working which gives you options in how, where and when you get your work done, including flexible working hours and home working.

NEXT STEPS…

If you feel this role is right for you, we’d love to hear from you.

To apply, please visit our website: https://www.f-star.com/about/careers/ and upload your CV for us to view. Those that shine brightest will be contacted to discuss the role further, however, we aim to get back to everyone with a response either way.

We may choose to close the role sooner than the application closing date depending on volume of candidates and so we encourage early applications.

If, along the way, you experience any difficulties with applying via our website, please email HR@f-star.com.

We aspire to be a diverse and inclusive workplace and strongly encourage suitably qualified applicants from a wide range of backgrounds to apply.

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