Research / Senior Research Associate – Protein Expression (12 month fixed term maternity cover)


Closing Date: 25/02/2022

Research / Senior Research Associate – Protein Expression (12 month fixed term maternity cover)


At F-star, we are dedicated to developing next generation immunotherapies to transform the lives of patients with cancer. We develop mAb², a novel class of disruptive bispecific antibody-based therapies that have the potential to overcome tumour resistance and restore anti-cancer immunity and responsiveness.

We are committed to delivering life-changing treatments for the estimated 80% of patients with cancer who currently fail to have a durable response to immunotherapies.

Our wholly owned pipeline shows focused and potent immune activation, with a promising safety profile to date.

We’re an agile, international team with dual headquarters in Cambridge, UK and Cambridge, Massachusetts. We empower our teams to decide where and when they work to deliver our goals.


We are looking for a Research / Senior Research Associate to join our Protein Sciences Team. This role is for a 12-month period in the first instance. You will be a key part of the Protein sciences group working in a laboratory-based role and be responsible for expression of recombinant proteins in mammalian cell lines.


• Design and execute cloning of fusion proteins, antibodies and bi-specific mAb2 for expression in mammalian cells using DNA assembly technologies in a timely manner.

• Produce and purify endotoxin free expression plasmids.

• Perform lab-scale transient expression of fusion proteins, antibodies and bispecific mAb2 in mammalian cell systems (HEK293).

• Maintain, expand and cryopreserve cell banks.

• Contribute to the maintenance of reagents and general lab facilities.

• Analyse and critically interpret data to draw results driven conclusions.

• Utilise understanding of recombinant protein expression to make proactive recommendations based on comprehensive interpretation of results.


We’re looking for someone who is adaptable, keen to learn and confident in delivering work with limited supervision. You’ll be organised with strong attention to detail with an ability to keep clear records. You will be able to maintain rigid controls and analysis during multiple experiments. Strong communication skills are important along with the proven ability to work well within teams, both in person and in a virtual environment. This is a busy role with deadlines to meet and so you’ll be able to prioritise your workload and adapt quickly to change when needed.


Demonstrates knowledge of technical principles, processes, and concepts, related to recombinant protein expression.


• Relevant experience in protein expression (molecular biology and cell culture).

• Knowledge and hands-on experiences in molecular biology techniques and vector design for expression of antibodies in mammalian systems (DNA manipulation, cloning, sequence alignment and analysis).

• Hands-on experience in transient expression of recombinant proteins using mammalian cell systems (HEK293 and CHO).


• Understanding of cell line generation process conforming to bioproduction requirement would be beneficial.

Education and Experience:

• Theoretical and practical scientific/technical knowledge of at least a relevant Bachelor of Science degree and/or a combination of education and experience.

• Good track record of relevant hands-on, lab-based experience ideally in industry


We get things done, we keep things simple, and we’re driven by the science. We’re ambitious so we work hard to create an environment where we can take smart risks. We want to be innovative so encourage debate and collaboration to challenge the usual way of doing things. We love our celebrations, socialising and perks, which make F-star a fun and diverse place to work. And most of all, everyone has the opportunity to make a difference.


• Pension (8% Employer contribution)

• Equity Incentives

• Private Medical Insurance and Health Cash Plan

• Life assurance

• 25 days paid holiday, plus the option to buy 5 days

• Travel insurance

• Enhanced Maternity, Paternity, Adoption pay

• Agile working opportunities


This role is to be based in Cambridge UK. Our laboratories and office space are based on the Babraham Research Campus, South Cambridgeshire.

This is a full time position working 37.5 hours per week. While this is primarily a laboratory based role, F-star is proud to fully embrace agile working which gives you options in how, where and when you get your work done, including flexible working hours and home working.


If you feel this role is right for you, we’d love to hear from you.

To apply, please visit our website: and upload your CV for us to view. Those that shine brightest will be contacted to discuss the role further, however, we aim to get back to everyone with a response either way.

We may choose to close the role sooner than the application closing date depending on volume of candidates and so we encourage early applications.

If, along the way, you experience any difficulties with applying via our website, please email

We aspire to be a diverse and inclusive workplace and strongly encourage suitably qualified applicants from a wide range of backgrounds to apply.

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