Research Associate – Characterisation

F-star

Closing Date: 24/02/2022

Research Associate – Characterisation

A BIT ABOUT US…

At F-star, we are dedicated to developing next generation immunotherapies to transform the lives of patients with cancer. We develop mAb², a novel class of disruptive bispecific antibody-based therapies that have the potential to overcome tumour resistance and restore anti-cancer immunity and responsiveness.

We are committed to delivering life-changing treatments for the estimated 80% of patients with cancer who currently fail to have a durable response to immunotherapies.

Our wholly owned pipeline shows focused and potent immune activation, with a promising safety profile to date.

We’re an agile, international team with dual headquarters in Cambridge, UK and Cambridge, Massachusetts. We empower our teams to decide where and when they work to deliver our goals.

YOUR ROLE IN OUR TEAM:

We are looking for a Research Associate to join our Protein Sciences Team. Working within the Protein Sciences group, you will proactively contribute to the development and delivery of analytical capabilities to support our technology platform and mAb2 bispecific pipeline. Analytical capabilities are required to deliver protein engineering, research grade production and process development activities with a key focus on protein characterisation and developability assessments.

YOUR KEY RESPONSIBILITIES WILL INCLUDE:

• Delivery of analytical methods for characterisation of F-star mAb2 pipeline with a key focus on SE HPLC, HIC HPLC, Ion exchange/ charge heterogeneity and analytical method development

• Formulation, characterisation and stability studies of mAb2 molecules

• Critical interpretation of data to draw results driven conclusions and define project progression

A BIT ABOUT YOU:

We’re looking for someone who is adaptable, keen to learn and confident in delivering work with limited supervision. You’ll be organised with strong attention to detail with an ability to keep clear records. You will be able to maintain rigid controls and analysis during multiple experiments. Strong communication skills are important along with the proven ability to work well within teams, both in person and in a virtual environment. This is a busy role with deadlines to meet and so you’ll be able to prioritise your workload and adapt quickly to change when needed.

YOUR SKILLS, KNOWLEDGE AND EXPERIENCE:

Essential:

• Bsc/MSc in relevant subject with relevant experience ideally in industry.

• Demonstrated experience in applying Chromatography techniques including UHPLC (SEC, RP, IEX)

• Demonstrate good knowledge of protein biophysical properties and stability

• Demonstrated scientific credibility and ability to drive decisions through scientific expertise; proven ability to interpret complex data

• Team player and ability to work in teams with different skills

• Solution-finding, and agility as evidenced by flexibility, adaptability to change, curiosity, and ability to lead and drive change

• Excellent verbal and written communication skills

Desirable:

• Experience and breadth of knowledge in analytical and biophysical characterisation of recombinant biotherapeutics for CMC development. (e.g. formulation, protein aggregation, protein stability and post-translational modifications including glycosylation).

• Demonstrated experience in analytical and biophysical characterisation of recombinant biotherapeutics.

• Knowledge of recombinant proteins

• Knowledge and experiences in biophysical methods for characterisation of protein conformation (Light Scattering, DSC, DSF, CD,)

WHAT WE CAN OFFER TO YOU:

We get things done, we keep things simple, and we’re driven by the science. We’re ambitious so we work hard to create an environment where we can take smart risks. We want to be innovative so encourage debate and collaboration to challenge the usual way of doing things. We love our celebrations, socialising and perks, which make F-star a fun and diverse place to work. And most of all, everyone has the opportunity to make a difference.

Benefits:

• Pension (8% Employer contribution)

• Equity Incentives

• Private Medical Insurance and Health Cash Plan

• Life assurance

• 25 days paid holiday, plus the option to buy 5 days

• Travel insurance

• Enhanced Maternity, Paternity, Adoption pay

• Agile working opportunities

OTHER DETAILS:

This role is to be based in Cambridge UK. Our laboratories and office space are based on the Babraham Research Campus, South Cambridgeshire.

This is a full time position working 37.5 hours per week. While this is primarily a laboratory-based role, F-star is proud to fully embrace agile working which gives you options in how, where and when you get your work done, including flexible working hours and home working.

NEXT STEPS…

If you feel this role is right for you, we’d love to hear from you.

To apply, please visit our website: https://www.f-star.com/about/careers/ and upload your CV for us to view. Those that shine brightest will be contacted to discuss the role further, however, we aim to get back to everyone with a response either way.

We may choose to close the role sooner than the application closing date depending on volume of candidates and so we encourage early applications.

If, along the way, you experience any difficulties with applying via our website, please email HR@f-star.com.

We aspire to be a diverse and inclusive workplace and strongly encourage suitably qualified applicants from a wide range of backgrounds to apply.

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